Kuo-Chiang Hsia

Website: Click

The spatial organization of the cellular cytoplasm has fascinated cell biologists since the advent of microscopy. My research is centered on unraveling the complexities underlying the organization and functionality of micron-sized microtubule arrays. Specifically, I investigate their roles in facilitating mitosis progression, ciliogenesis, and neuronal maturation. Additionally, I explore how nuclear transport factors influence the organization of microtubule-based structures, such as the spindle and anemone, through both canonical and non-canonical activities. Beyond fundamental cell biology, my research extends to understanding the molecular mechanisms underlying cancer drug resistance. Given the significance of tubulin as a target for anti-cancer drugs, we are focusing on elucidating the mechanisms responsible for drug resistance. This study aims to deepen our understanding of cancer drug resistance and potentially uncover new avenues for the development of more effective cancer treatments. In pursuit of these objectives, we reconstitute and image the self-organization of microtubule-based structures from the protein building blocks. In the lab, we apply an interdisciplinary approach, including biochemical, structural biology, biophysical and cell biology methods, to uncover cellular mechanisms. Through our endeavors, the ultimate goal is to unveil the mechanistic links connecting cytoskeletal organization with essential cell functions.